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Search Results for " phosphodiesterase 3 "

48

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21389	Enprofylline Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱	Others	Others
	Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。
T5956	VP3.15 dihydrobromide	GSK-3; PDE	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	VP3.15 dihydrobromide 是一种口服具有活力的、高效的、CNS 可渗透的PDE7-GSK3双重抑制剂，对 PDE7 和 GSK3 作用的IC50值分别为 1.59 μM 和 0.88 μM。它具有神经保护和神经修复作用，可用于研究多发性硬化症 (MS) 潜在的抗炎和促髓鞘再生联合。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T1713	IBMX IBMX,3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine	PDE	Metabolism
	IBMX (Methylisobutylxanthine) 是一种广谱的磷酸二酯酶 (PDE) 抑制剂，对 PDE3、PDE4 和 PDE5 均有抑制活性 (IC50=6.5/26.3/31.7 μM)。IBMX 可以增强细胞内 cAMP 水平。
T16164	MY-5445 N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE	Metabolism
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂，其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂，具有抗增殖活性。它能抑制人血小板凝集。
T19706	Ro 20-1724 Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE	Metabolism
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其 Ki=1930 nM，具有神经保护作用。
T1096	Milrinone Win 47203,米力农	PDE	Metabolism
	Milrinone (Win 47203) 是一种 PDE3抑制剂，也是一种强心药、血管舒张药。
T0462	Cilostazol 西洛他唑,OPC 21,OPC 13013	PDE; Autophagy	Autophagy; Metabolism
	Cilostazol (OPC 21) 是一种选择性的心血管系统中磷酸二酯酶 3 亚型PDE 3A 的抑制剂，IC50值为 0.2 μM。
T19865	GEBR-7b 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE	Metabolism
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) 是一种磷酸二酯酶 4 (PDE4) 抑制剂。
T12267	NSP-805	PDE	Metabolism
	NSP-805 是一种强心剂，是一种选择性的 phosphodiesterase 3 抑制剂，具有舒张血管的作用。
T6644	Rolipram SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram	HIV Protease; Antibacterial; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Rolipram (SB 95952) 是一种磷酸二酯酶 PDE4的选择性抑制剂，抑制 PDE4A，PDE4B 和 PDE4D 的 IC50分别为 3 nM，130 nM 和 240 nM。
T1265	Amrinone Inamrinone,Inocor,氨力农,Wincoram	TNF; PDE	Apoptosis; Metabolism
	Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。
T3465L	Vesnarinone HCl Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel; Calcium Channel; PDE	Membrane transporter/Ion channel; Metabolism
	Vesnarinone HCl (OPC-8212 HCl) 是一种具有口服活性的 phosphodiesterase 3 (PDE3) 抑制剂。Vesnarinone HCl 可对钙离子和钾离子进行调节，增加钙通量，减少钾通量。Vesnarinone HCl 是一种新的正性肌力化合物，可增强心肌收缩力，可用于心力衰竭的研究。
T5033	Olprinone 奥普力农,Loprinone	PDE	Metabolism
	Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。
T0160	Anagrelide Anagrelida,Xagrid,Anagrelidum,阿那格雷	PDE	Metabolism
	Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM)，是咪唑喹唑啉衍生物。它能够抑制血小板生成，以及抗血栓形成作用，可用作血小板聚集抑制剂。
T10667	Calmidazolium chloride R 24571,钙调蛋白抑制剂	CaMK; Autophagy	Autophagy; Neuroscience
	Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂，对CaM 依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP 酶活化有拮抗作用，IC50分别为0.15和0.35 μM。Calmidazolium chloride 结合CaMK 的Kd 值为3 nM。Calmidazolium chloride 在抗癌领域有研究的价值。
T1024	Roflumilast 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217	PDE; RSV	Metabolism; Microbiology/Virology
	Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4)，具有抗炎和潜在的抗肿瘤活性，作用于PDE4A1，PDEA4，PDEB1和PDEB2，IC50分别为 0.7，0.9，0.7 和 0.2 nM。
T25463	Griseolic acid
	Griseolic acid is a cyclic adenosine 3',5'-monophosphate phosphodiesterase II inhibitor.
T12391	PDE1-IN-3	Others	Others
	PDE1-IN-3 is a selective inhibitor of human phosphodiesterase 1 (PDE1).
T15714	LAS-31180	Others	Others
	LAS-31180 is a phosphodiesterase 3 inhibitor. It also has positive inotropic and vasodilator properties.
T12392	PDE12-IN-3	Others	Others
	PDE12-IN-3 is an inhibitor of phosphodiesterase 12 (PDE12) (pXC50 of 7.68),with antiviral activity.
T26767	Benafentrine dimaleate Benafentrine
	Benafentrine dimaleate is a platelet activating factor receptor (PAFR) antagonists and phosphodiesterase (PDE) 3/4 inhibitors.
T69159	AY-22,252
	AY-22,252 is an inhibitor of beef heart & rat brain nucleoside-3',5'- monophosphate phosphodiesterase.
T68716	AY 17,605
	AY 17,605 is an inhibitor of bovine heart and rat brain nucleoside-3',5'- monophosphate phosphodiesterase.
T13310	VP3.15	Others	Others
	VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).
T15640	K134 OPC33509	PDE	Metabolism
	K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.
T32348	K 259-3 K2593
	K 259-3 是 K 259-2 的甲酯，是钙调素依赖性环核苷酸磷酸二酯酶的抑制剂。
T69593	Sildenafil nitrate
	Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).
T61208	PDE4-IN-11
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3].
T40356	PDE4-IN-3 PDE4-IN-3
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T32156	Indimilast
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
T60417	Fenspiride
	Fenspiride 是 H1-组胺受体的拮抗剂。 Fenspiride 是一种具有口服活性的非甾体类抗炎药，可用于治疗呼吸道感染和中耳炎。 Fenspiride 抑制磷酸二酯酶 4 和磷酸二酯酶 3 的活性，-logIC50 值分别为 4.16+/-0.09 和 3.44+/-0.12。磷酸二酯酶 5 活性也受到抑制，-logIC50 值约为 3.8。
T69491	(E/Z)-Ensifentrine
	(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials.
T78559	PDE7-IN-3
	PDE7-IN-3（例2）是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂，可用于探究炎性、神经性、内脏性及伤害性疼痛。
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop...
T36133	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 \|1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).\|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, ...
T36547	Quazinone
	Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smoot...
T76138	Phosphodiesterase
	Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶，常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根据其对环核苷酸的特异性也可以分别不同类型，如 PDE1-PDE11，在多种疾病方面也具有一定的潜力。
T82989	AP-C6
	AP-C6 是一种有效的 cGMP 依赖性蛋白激酶 II (cGKII) 抑制剂，其 pIC50 值为 6.5。该化合物能够在体外浓度依赖性地抑制人 cGKII 的活性，并能够通过抑制 PDE 来增强 cAMP 信号传导。
T5033L	Olprinone Hydrochloride
	Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 由于具有正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。
T75790	CALP2 TFA
	CALP2 TFA 是一种钙调蛋白 (CaM) 拮抗剂 (Kd 为 7.9 µM)，以亲和力结合CaMEF-hand/Ca2+结合位点。CALP2 TFA 抑制CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性并增加细胞内 Ca2+浓度。CALP2 TFA 有效抑制粘附和脱粒。CALP2 TFA 还是肺泡巨噬细胞的强激活剂。
T73708	Sp-cAMPS triethylamine
	Sp-cAMPS triethylamine，一种 cAMP 类似物，是一种依赖 cAMP 的PKAI 和PKAII 的有效激活剂。Sp-cAMPS triethylamine 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS triethylamine 以EC50为 40 μM 来结合PDE10GAF 域。
T75791	CALP1 TFA
	CALP1 TFA 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM)，与 CaMEF-hand/Ca2+结合位点结合。CALP1 TFA 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50为 44.78 µM)。CALP1 TFA 阻止谷氨酸受体 (glutamate receptor channels) 通道，并阻止存储操作的非选择性阳离子通道。CALP1 TFA 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T21697	Sp-Cyclic AMPS (sodium salt)
	Sp-cAMPS sodium salt 作为 cAMP 类似物，是一种依赖 cAMP 的PKA I 和PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 μM。Sp-cAMPS sodium salt 结合PDE10 GAF 结构域，EC50为 40 μM 。
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...
T35929	O-Demethyl Apremilast
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi...
T60511	Theophylline sodium glycinate
	Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。

化合物

Cat.No: T21389

Synonym: Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱

Target: Others

VP3.15 dihydrobromide

Cat.No: T5956

Target: GSK-3, PDE

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T1713

Synonym: IBMX,3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine

Target: PDE

Cat.No: T16164

Synonym: N-(3-chlorophenyl)-4-phenylphthalazin-1-amine

Target: PDE

Cat.No: T19706

Synonym: Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724

Target: PDE

Cat.No: T1096

Synonym: Win 47203,米力农

Target: PDE

Cat.No: T0462

Synonym: 西洛他唑,OPC 21,OPC 13013

Target: PDE, Autophagy

Cat.No: T19865

Synonym: 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde

Target: PDE

Cat.No: T12267

Target: PDE

Cat.No: T6644

Synonym: SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram

Target: HIV Protease, Antibacterial, PDE

Cat.No: T1265

Synonym: Inamrinone,Inocor,氨力农,Wincoram

Target: TNF, PDE

Vesnarinone HCl

Cat.No: T3465L

Synonym: Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)

Target: Potassium Channel, Calcium Channel, PDE

Cat.No: T5033

Synonym: 奥普力农,Loprinone

Target: PDE

Cat.No: T0160

Synonym: Anagrelida,Xagrid,Anagrelidum,阿那格雷

Target: PDE

Calmidazolium chloride

Cat.No: T10667

Synonym: R 24571,钙调蛋白抑制剂

Target: CaMK, Autophagy

Cat.No: T1024

Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

Target: PDE, RSV

Cat.No: T25463

Cat.No: T12391

Target: Others

Cat.No: T15714

Target: Others

Cat.No: T12392

Target: Others

Benafentrine dimaleate

Cat.No: T26767

Synonym: Benafentrine

Cat.No: T69159

Cat.No: T68716

Cat.No: T13310

Target: Others

Cat.No: T15640

Synonym: OPC33509

Target: PDE

Cat.No: T32348

Synonym: K2593

Sildenafil nitrate

Cat.No: T69593

Cat.No: T61208

Cat.No: T40356

Synonym: PDE4-IN-3

Cat.No: T32156

Cat.No: T60417

(E/Z)-Ensifentrine

Cat.No: T69491

Cat.No: T78559

Cat.No: T69262

3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Cat.No: T36133

Cat.No: T36547

Phosphodiesterase

Cat.No: T76138

Cat.No: T82989

Olprinone Hydrochloride

Cat.No: T5033L

Cat.No: T75790

Sp-cAMPS triethylamine

Cat.No: T73708

Cat.No: T75791

Cat.No: T63776

Sp-Cyclic AMPS (sodium salt)

Cat.No: T21697

Cat.No: T37832

Synonym: CAY10761

O-Demethyl Apremilast

Cat.No: T35929

Theophylline sodium glycinate

Cat.No: T60511

Cat. No.	Product Name	Target	Signaling Pathways
TN1266	3-O-Methylquercetin	IL Receptor; cAMP; PDE	GPCR/G Protein; Immunology/Inflammation; Metabolism
	3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物，可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。
T17199	Udenafil 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非	PDE	Metabolism
	Udenafil 是一种选择性的，有效的，具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解，可用于研究勃起功能障碍的。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN2974	3-O-Methylquercetin tetraacetate	IL Receptor; TNF; PDE	Apoptosis; Immunology/Inflammation; Metabolism
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
TN1841	Kushenol A 苦参新醇 A,Leachianone E	cAMP	GPCR/G Protein
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
TN4886	Quinovic acid 3-O-alpha-L-rhamnopyranoside	Others	Others
	Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.

天然产物

3-O-Methylquercetin

Cat.No: TN1266

Target: IL Receptor, cAMP, PDE

Cat.No: T17199

Synonym: 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非

Target: PDE

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

3-O-Methylquercetin tetraacetate

Cat.No: TN2974

Target: IL Receptor, TNF, PDE

Cat.No: TN1841

Synonym: 苦参新醇 A,Leachianone E

Target: cAMP

Quinovic acid 3-O-alpha-L-rhamnopyranoside

Cat.No: TN4886

Target: Others

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

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